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贺超良

贺超良
姓 名:贺超良
邮 箱:clhe@ciac.ac.cn
职 称:研究员
研究方向:
 I. 个人信息:

姓名:贺超良

职称:研究员

工作单位:中国科学院长春应用化学研究所,生态环境高分子材料重点实验室

单位地址:中国吉林省长春市人民大街5625号,邮编130022

电话:0431-85262116

E-mailclhe@ciac.ac.cn

 

II. 研究领域:

(1)  可注射性聚氨基酸仿生水凝胶的设计、制备与生物医学应用

(2)  抗肿瘤药物局部缓释载体材料、组织再生支架材料

(3)  生物响应性与生物活性高分子材料的设计与合成

 

III. 学习经历:

2001.92007.1,理学博士, 高分子化学与物理专业,中国科学院长春应用化学研究所

1997.92001.7,工学学士,应用化学专业,华东理工大学

 

IV. 工作经历:

2016.1 – 至今,研究员,中国科学院长春应用化学研究所,生态环境高分子材料重点实验室

2010.9 – 2015.12,副研究员,中国科学院长春应用化学研究所,生态环境高分子材料重点实验室

2008.112010.8,博士后,渥太华大学,渥太华健康研究所,加拿大安大略省渥太华市。

2007.32008.8,博士后,韩国成钧馆大学,韩国京畿道水原市。

 

V. 科研项目来源:

国家自然科学基金委、中国科学院、吉林省科学技术厅

 

VI. 主要荣誉:

2016年获得国家自然科学基金委“优秀青年科学基金”

2013年入选中国科学院青年创新促进会

 

VII. 学术论文与专利情况:

发表IF>5SCI论文30余篇,论文SCI他引2000余次;获得授权中国发明专利10余项。

 

a) 近年代表性论文:

1.       Chaoliang He, Zhaohui Tang, Huayu Tian, Xuesi Chen*. Co-delivery of chemotherapeutics and proteins for synergistic therapy. Advanced Drug Delivery Reviews 2016, 98, 64-76.

2.       Qinghua Xu, Chaoliang He*, Kaixuan Ren, Chunsheng Xiao, Xuesi Chen*. Thermosensitive polypeptide hydrogels as a platform for ROS-triggered cargo release with innate cytoprotective ability under oxidative stress. Advanced Healthcare Materials 2016, 5(15), 1979-1990.

3.       Qinghua Xu, Chaoliang He*, Chunsheng Xiao, Xuesi Chen*. Reactive oxygen species (ROS) responsive polymers for biomedical applications. Macromolecular Bioscience 2016, 16(5), 635-646.

4.       Xilong Wu, Chaoliang He*, Yundi Wu, Xuesi Chen*. Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model. Biomaterials 2016, 75, 148-162.

5.       Zhaohui Tang, Chaoliang He, Huayu Tian, Jianxun Ding, Benjamin S Hsiao*, Benjamin Chu, Xuesi Chen*. Polymeric nanostructured materials for biomedical applications. Progress in Polymer Science 2016, DOI: 10.1016/j.progpolymsci.2016.05.005.

6.       Kaixuan Ren, Chaoliang He*, Chunsheng Xiao, Gao Li*, Xuesi Chen. Injectable glycopolypeptide hydrogels as biomimetic scaffolds for cartilage tissue engineering. Biomaterials 2015, 51, 238-249.

7.       Qinghua Xu, Chaoliang He*, Chunsheng Xiao, Shuangjiang Yu, Xuesi Chen*. ε-methacryloyl-L-Lysine based polypeptides and their thiol-ene click functionalization. Polymer Chemistry 2015, 6(10), 1758-1767.

8.       Xilong Wu, Chaoliang He, Yundi Wu, Xuesi Chen*, Jianjun Cheng*. Nanogel-incorporated physical and chemical hybrid gels for highly effective chemo-protein combination therapy. Advanced Functional Materials 2015, 25 (43), 6744-6755.

9.       Kaixuan Ren, Chaoliang He*, Yilong Cheng, Gao Li*, Xuesi Chen. Injectable enzymatically crosslinked hydrogels based on a poly(L-glutamic acid) graft copolymer. Polymer Chemistry 2014, 5(17), 5069-5076.

10.    Shuangjiang Yu, Jianxun Ding, Chaoliang He*, Yue Cao, Weiguo Xu, Xuesi Chen. Disulfide cross-linked polyurethane micelles as a reduction-triggered drug delivery system for cancer therapy. Advanced Healthcare Materials 2014, 3(5), 752-760.

11.    Xiaoye Gao, Yue Cao, Xiangfu Song, Zhe Zhang, Chunsheng Xiao, Chaoliang He*, Xuesi Chen. pH- and thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid derivative) copolymers and hydrogels with LCST dependent on pH and alkyl side groups. Journal of Materials Chemistry B 2013, 1(41), 5578-5587.

12.    Shuangjiang Yu, Chaoliang He*, Jianxun Ding, Yilong Cheng, Wantong Song, Xiuli Zhuang, Xuesi Chen. pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery. Soft Matter 2013, 9(9), 2637-2645.

13.    Kaixuan Ren, Yilong Cheng, Chaoliang He*, Chunsheng Xiao, Gao Li*, Xuesi Chen. The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers. Polymer 2013, 54(9), 2466-2472.

14.    Yilong Cheng, Chaoliang He, Jianxun Ding, Chunsheng Xiao, Xiuli Zhuang, Xuesi Chen*. Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs. Biomaterials 2013, 34(38), 10338-10347.

15.    Yilong Cheng, Chaoliang He, Chunsheng Xiao, Jianxun Ding, Haitao Cui, Xiuli Zhuang, Xuesi Chen*. Versatile biofunctionalization of polypeptide-based thermosensitive hydrogels via click chemistry. Biomacromolecules 2013, 14(2), 468-475.

16.    Chaoliang He, Xiuli Zhuang, Zhaohui Tang, Huayu Tian, Xuesi Chen*. Stimuli-sensitive synthetic polypeptide-based materials for drug and gene delivery. Advanced Healthcare Materials 2012, 1 (1), 48-78.

17.    Yilong Cheng, Chaoliang He, Chunsheng Xiao, Jianxun Ding, Xiuli Zhuang, Yubin Huang, Xuesi Chen*. Decisive role of hydrophobic side groups of polypeptides in thermosensitive gelation. Biomacromolecules 2012, 13 (7), 2053-2059.

 

b) 主要授权专利:

1.       贺超良、任凯旋、成一龙、肖春生、李杲、陈学思,一种类糖肽及其制备方法、可注射性水凝胶,中国发明专利,申请日:2014.4.10,授权日:2016.3.30,专利号:201410142607.3

2.       贺超良、徐清华、成一龙、肖春生、于双江、陈学思,聚(ε-甲基丙烯酰基-L-赖氨酸)均聚物、嵌段共聚物及功能化聚合物,中国发明专利,申请日:2013.10.12,授权日:2016.1.20,专利号:201310478189.0

3.       贺超良、成一龙、于双江、任凯旋、庄秀丽、陈学思,还原敏感聚氨基酸纳米水凝胶及其制备方法,中国发明专利,申请日:2013.4.3,授权日:2016.1.13,专利号:201310115466.1

4.       贺超良、任凯旋、成一龙、李杲、陈学思,聚氨基酸接枝共聚物及其制备方法、可注射性水凝胶,中国发明专利,申请日:2013.9.26,授权日:2015.9.16,专利号:201310446018.X

5.       贺超良、成一龙、庄秀丽、陈学思,聚氨基酸嵌段共聚物、其制备方法及温度敏感型水凝胶,中国发明专利,申请日:2012.11.28,授权日:2015.1.21,专利号:201210496188.4

6.       贺超良、成一龙、庄秀丽、肖春生、丁建勋、陈学思,聚(γ-丙炔基-L-谷氨酸酯)嵌段共聚物、其制备方法及水凝胶,中国发明专利,申请日:2011.1.21,授权日:2012.9.19,专利号:201110023965.9

7.       贺超良、成一龙、肖春生、丁建勋、任凯旋、庄秀丽、陈学思,一种嵌段共聚物、其制备方法及温度敏感水凝胶,中国发明专利,申请日:2011.11.14,授权日:2013.3.27,专利号:201110359738.3

8.       贺超良、于双江、成一龙、肖春生、丁建勋、庄秀丽、陈学思,含有二硫键和三级胺基团的聚氨酯嵌段共聚物及其制备方法,中国发明专利,申请日:2012.2.15,授权日:2014.2.26,专利号:201210032905.8

9.       贺超良、于双江、庄秀丽、陈学思,一种聚氨酯嵌段共聚物、其制备方法及其纳米水凝胶,中国发明专利,申请日:2012.10.19,授权日:2014.7.2,专利号:201210401496.4

10.    贺超良、高晓晔、庄秀丽、陈学思,聚(N-异丙基丙烯酰胺)-聚(丙烯酸或丙烯酸衍生物)共聚物及其制备方法,中国发明专利,申请日:2012.11.6,授权日:2014.8.27,专利号:201210438766.9

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