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人员介绍

田华雨

田华雨
姓 名:田华雨
邮 箱:thy@ciac.ac.cn
职 称:研究员
研究方向:


教育经历

2002.9-2005.12

中科院长春应用化学研究所,高分子化学专业,博士

1998.9-2000.7

哈尔滨工业大学,高分子材料专业,硕士

1994.9-1998.7

哈尔滨工业大学,高分子材料专业,本科

 
工作经历

2013.1-现在

中科院长春应用化学研究所,研究员

2009.8-2010.9

美国犹他大学,访问学者

2008.8-2012.12

中科院长春应用化学研究所,副研究员

2006.3-2008.8

中科院长春应用化学研究所,助理研究员

2000.7-2002.8

山东新立克基团,研发中心职员


目前研究领域和研究兴趣

[1]  生物医用高分子
[2]  纳米基因/药物载体
[3]  干细胞治疗
[4]  DNA疫苗
[5]  高分子基因载体介导的抗肿瘤治疗
 


发表论文

[1] Guan X, Guo Z, Wang T, Lin L, Chen J, Tian H, et al. A pH-Responsive Detachable PEG Shielding Strategy for Gene Delivery System in Cancer Therapy. Biomacromolecules. 2017. DOI: 10.1021/acs.biomac.7b00080.
[2] Chen J, Guo Z, Lin L, Hu Y, Tian H, Chen M, et al. Combination therapy of pDNA and siRNA by versatile carriers composed of poly (L-serine) modified polyethylenimines. Materials Chemistry Frontiers. 2017. DOI: 10.1039/c6qm00270f.
[3] Chen J, Guan X, Hu Y, Tian H, Chen X. Peptide-Based and Polypeptide-Based Gene Delivery Systems. Top Curr Chem (J). 2017;375:32.
[4] Abid Sheikh M, Saeed Malik Y, Xing Z, Guo Z, Tian H, Zhu X, et al. Polylysine-modified polyethylenimine (PEI-PLL) mediated VEGF gene delivery protects dopaminergic neurons in cell culture and in rat models of Parkinson's Disease (PD). Acta Biomater. 2017. DOI: 10.1016/j.actbio.2016.12.048.
[5] Xu C, Tian H, Wang P, Wang Y, Chen X. The suppression of metastatic lung cancer by pulmonary administration of polymer nanoparticles for co-delivery of doxorubicin and Survivin siRNA. Biomater Sci-Uk. 2016;4:1646-54. 
[6] Xia J, Tian H, Chen J, Guo Z, Lin L, Yang H, et al. Polyglutamic acid based polyanionic shielding system for polycationic gene carriers. Chinese J Polym Sci. 2016;34:316-23.
[7] Xia J, Tian H, Chen J, Lin L, Guo Z, Han B, et al. pH-Triggered Sheddable Shielding System for Polycationic Gene Carriers. Polymers-Basel. 2016;8:141.
[8] Xia J, Chen J, Lin L, Guo Z, Han B, Yang H, et al. Sulfathiazole grafted PEG-PLL as pH-sensitive shielding system for cationic gene delivery. Polym Bull. 2016:1-9.
[9] Wang P, Lin L, Guo Z, Chen J, Tian H, Chen X, et al. Highly Fluorescent Gene Carrier Based on Ag-Au Alloy Nanoclusters. Macromol Biosci. 2016;16:160-7.
[10] Lin L, Guo Z, Chen J, Tian H, Chen X. Synthesis and Characterization of Polyphenylalanine Grafted Low Molecular Weight PEI as Efficient Gene Carriers. Acta Polym Sin. 2016:DOI:10.11777/j.issn1000-3004.2017.6277.
[11] Lin L, Chen J, Guo Z, Song W, Zhang D, Tian H, et al. Exploring the in vivo fates of RGD and PEG modified PEI/DNA nanoparticles by optical imaging and optoacoustic imaging. Rsc Adv. 2016;6:112552-61.
[12] Guan X, Guo Z, Lin L, Chen J, Tian H, Chen X. Ultrasensitive pH Triggered Charge/Size Dual-Rebound Gene Delivery System. Nano Lett. 2016;16:6823-31.
[13] Chen J, Lin L, Guo Z, Xu C, Li Y, Tian H, et al. N-Isopropylacrylamide Modified Polyethylenimines as Effective siRNA Carriers for Cancer Therapy. J Nanosci Nanotechno. 2016;16:5464-9.
[14] Chen J, Liang H, Lin L, Guo Z, Sun P, Chen M, et al. Gold Nanorods-Based Gene Carriers with the Capability of Photoacoustic Imaging and Photothermal Therapy. Acs Appl Mater Inter. 2016; 8:31558-66
[15] Chen J, Guo Z, Tian H, Chen X. Production and clinical development of nanoparticles for gene delivery. Molecular Therapy Methods & Clinical Development. 2016;3:16023.
[16] Xu CN, Wang P, Zhang JP, Tian HY, Park K, Chen XS. Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer. Small. 2015;11:4321-33.
[17] Xu CN, Tian HY, Sun H, Jiao ZX, Zhang Y, Chen XS. A pH sensitive co-delivery system of siRNA and doxorubicin for pulmonary administration to B16F10 metastatic lung cancer. Rsc Adv. 2015;5:103380-5.
[18] Li YH, Zhang JP, Zhang W, Tian HY, Chen XS. Novel microcapsules for drug and gene delivery. J Control Release. 2015;213:E130-E1.
[19] Li YC, Tian HY, Ding JX, Lin L, Chen J, Gao SQ, et al. Guanidinated Thiourea-Decorated Polyethylenimines for Enhanced Membrane Penetration and Efficient siRNA Delivery. Adv Healthc Mater. 2015;4:1369-75.
[20] Jiao ZX, Cen J, Tian HY, Chen XS. Synergistic Antitumor Effect of Cisplatin and siRNA Mediated by Polyethylenimine. Acta Polym Sin. 2015:127-32.
[21] He CL, Ma HC, Cheng YL, Li DS, Gong YB, Liu JG, et al. PLK1shRNA and doxorubicin co-loaded thermosensitive PLGA-PEG-PLGA hydrogels for localized and combined treatment of human osteosarcoma. J Control Release. 2015;213:E18-E.
[22] Guan XW, Li YH, Jiao ZX, Lin LL, Chen J, Guo ZP, et al. Codelivery of Antitumor Drug and Gene by a pH-Sensitive Charge-Conversion System. Acs Appl Mater Inter. 2015;7:3207-15.
[23] Feng TS, Tian HY, Xu CN, Lin L, Lam MHW, Liang HJ, et al. Doxorubicin-loaded PLGA microparticles with internal pores for long-acting release in pulmonary tumor inhalation treatment. Chinese J Polym Sci. 2015;33:947-54.
[24] Feng TS, Tian HY, Dong X, Lam MHW, Liang HJ, Chen XS. pH-sensitive OEI-poly(aspartic acid-b-lysine) as charge shielding system for gene delivery. J Control Release. 2015;213:E104.
[25] Chen J, Lin L, Guo ZP, Xu CN, Tian HY, Park K, et al. Synergistic treatment of cancer stem cells by combinations of antioncogenes and doxorubicin. J Drug Deliv Sci Tec. 2015;30:417-23.
[26] Chen J, Li XZ, Tian HY, Zhu XJ, Chen XS. Application of Zwitterionic Polymers in the Treatment of Malignant Tumors. Chem J Chinese U. 2015;36:2148.
[27] Chen J, Jiao ZX, Lin L, Guo ZP, Xu CN, Li YH, et al. Polylysine-modified polyethylenimines as siRNA carriers for effective tumor treatment. Chinese J Polym Sci. 2015;33:830-7.
[28] Chen J, Dong X, Feng TS, Lin L, Guo ZP, Xia JL, et al. Charge-conversional zwitterionic copolymer as pH-sensitive shielding system for effective tumor treatment. Acta Biomater. 2015;26:45-53.
[29] Xu CN, Tian HY, Chen XS. Pulmonary Drugs and Genes Delivery Systems for Lung Disease Treatment. Chinese J Chem. 2014;32:13-21.
[30] Tian HY, Guo ZP, Lin L, Jiao ZX, Chen J, Gao SQ, et al. pH-responsive zwitterionic copolypeptides as charge conversional shielding system for gene carriers. J Control Release. 2014;174:117-25.
[31] Ma HC, He CL, Cheng YL, Li DS, Gong YB, Liu JG, et al. PLK1shRNA and doxorubicin co-loaded thermosensitive PLGA-PEG-PLGA hydrogels for osteosarcoma treatment. Biomaterials. 2014;35:8723-34.
[32] Guo ZP, Tian HY, Lin L, Chen J, He CL, Tang ZH, et al. Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier. Macromol Biosci. 2014;14:1406-14.
[33] Feng TS, Tian HY, Xu CN, Lin L, Xie ZG, Lam MHW, et al. Synergistic co-delivery of doxorubicin and paclitaxel by porous PLGA microspheres for pulmonary inhalation treatment. Eur J Pharm Biopharm. 2014;88:1086-93.
[34] Feng TS, Dong X, Tian HY, Lam MHW, Liang HJ, Wei Y, et al. PEGylated poly(aspartate-g-OEI) copolymers for effective and prolonged gene transfection. J Mater Chem B. 2014;2:2725-32.
[35] Chen J, Xia JL, Tian HY, Tang ZH, He CL, Chen XS. Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine. Arch Pharm Res. 2014;37:142-8.
[36] Tian HY, Lin L, Jiao ZX, Guo ZP, Chen J, Gao SQ, et al. Polylysine-modified polyethylenimine inducing tumor apoptosis as an efficient gene carrier. J Control Release. 2013;172:410-8.
[37] Tian HY, Chen J, Chen XS. Nanoparticles for Gene Delivery. Small. 2013;9:2034-44.
[38] Guan XW, Li YH, Jiao ZX, Chen J, Guo ZP, Tian HY, et al. A pH-sensitive charge-conversion system for doxorubicin delivery. Acta Biomater. 2013;9:7672-8.
[39] Dong X, Lin L, Chen J, Tian H, Xiao C, Guo Z, et al. Multi-armed poly(aspartate-g-OEI) copolymers as versatile carriers of pDNA/siRNA. Acta Biomater. 2013;9:6943-52.
[40] Dong X, Lin L, Chen J, Guo ZP, Tian HY, Li YC, et al. A Serum-Tolerant Hydroxyl-Modified Polyethylenimine as Versatile Carriers of pDNA/siRNA. Macromol Biosci. 2013;13:512-22.
[41] Chen J, Tian HY, Dong X, Guo ZP, Jiao ZX, Li FF, et al. Effective Tumor Treatment by VEGF siRNA Complexed with Hydrophobic Poly(Amino Acid)-Modified Polyethylenimine. Macromol Biosci. 2013;13:1438-46.
[42] Tian HY, Tang ZH, Zhuang XL, Chen XS, Jing XB. Biodegradable synthetic polymers: Preparation, functionalization and biomedical application. Prog Polym Sci. 2012;37:237-80.
[43] Tian HY, Li FF, Chen J, Huang YB, Chen XS. N-Isopropylacrylamide-Modified Polyethylenimines as Effective Gene Carriers. Macromol Biosci. 2012;12:1680-8.
[44] Tian HY, Guo ZP, Chen J, Lin L, Xia JL, Dong X, et al. PEI Conjugated Gold Nanoparticles: Efficient Gene Carriers with Visible Fluorescence. Adv Healthc Mater. 2012;1:337-41.
[45] Fu CL, Lin L, Shi HL, Zheng DX, Wang W, Gao SQ, et al. Hydrophobic poly (amino acid) modified PEI mediated delivery of rev-casp-3 for cancer therapy. Biomaterials. 2012;33:4589-96.
[46] Chen J, Tian HY, Guo ZP, Lin L, Dong X, Zhu XJ, et al. Hyperbranched PEI Grafted by Hydrophilic Amino Acid Segment Poly[N-(2-hydroxyethyl)-L-glutamine] as an Efficient Nonviral Gene Carrier. J Appl Polym Sci. 2012;123:2257-65.
[47] Tian HY, Lin L, Chen J, Chen XS, Park TG, Maruyama A. RGD targeting hyaluronic acid coating system for PEI-PBLG polycation gene carriers. J Control Release. 2011;155:47-53.
[48] Chen J, Tian HY, Kano A, Maruyama A, Chen XS, Park TG. In vitro and in vivo gene delivery using polyethylenimine-poly (hydroxyethyl glutamine) as a non-viral carrier. J Control Release. 2011;152:E134-E6.
[49] Guo ZP, Tian HY, Xia JL, Chen J, Lin L, Chen XS. Bioreducible crosslinked low molecular weight branched PEI-PBLG as an efficient gene carrier. Science China-Chemistry. 2010;53:2490-6.
[50] Chen J, Tian HY, Guo ZP, Xia JL, Kano A, Maruyama A, et al. A Highly Efficient siRNA Carrier of PBLG Modified Hyperbranched PEI. Macromol Biosci. 2009;9:1247-53.
[51] Tian HY, Xiong W, Wei JZ, Wang Y, Chen XS, Jing XB, et al. Gene transfection of hyperbranched PEI grafted by hydrophobic amino acid segment PBLG. Biomaterials. 2007;28:2899-907.
[52] Tian HY, Xia JL, Lin H, Chen L, Chen XS, Li YS, et al. Self-assembly of amphiphilic linear-hyperbranched multi-arm copolymer into cationic vesicles. Chem J Chinese U. 2006;27:1771-4.
[53] Tian HY, Chen XS, Lin H, Deng C, Zhang PB, Wei Y, et al. Micellization and reversible pH-sensitive phase transfer of the hyperbranched multiarm PEI-PBLG copolymer. Chem-Eur J. 2006;12:4305-12.
[54] Tian HY, Deng C, Lin H, Sun JR, Deng MX, Chen XS, et al. Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization. Biomaterials. 2005;26:4209-17.

 

获奖情况

2011年吉林省科技进步一等奖
2007年吉林省科技进步一等奖
2011年中国科学院青年创新促进会会员
2012年中国科学院青年创新促进会会员
2012年国家自然科学基金优秀青年基金
2014年中组部“万人计划”青年拔尖人才
2016年中国科学院青年创新促进会优秀会员

主持项目情况

[
1] 吉林省重点科技攻关项目,20160204032GX,具有诊疗功能的基因载体的构建与产 品开发,2016/01-2018/12,50万元,在研,主持 
[2] 国家自然科学基金面上项目,21474104,用于间充质干细胞的高分子基因载体的设 计制备和抗肿瘤治疗研究,2015/01-2018/12,88万元,在研,主持

[3] 中组部“万人计划”青年拔尖人才,2014年,240万元 
[4] 国家自然科学基金优秀青年基金,51222307,高分子基因载体,2013/01-2015/12 ,100万元,主持 

[5] 吉林省科技发展计划中青年科技创新领军人才及团队项目,20130521011JH,2013/ 01-20105/12,20万,主持 
[6] 吉林省科技发展计划重点项目,20120306,高分子基因载体的构建及肿瘤基因治疗 研究,2012/07-2014/12,28万元,主持 
[7] 中国科学院青年创新促进会, 2012/01-2015/12,40万 
[8] 国家自然科学基金面上项目,21074129,具有荧光和胞内控制释放性能的非病毒基 因载体,2011/01-2013/12,36万,主持 
[9] 国家自然科学基金面上项目,50873102,具有细胞识别和胞内裂解功能的高分子基 因载体体系的研究,2009/01-2011/12,35万,已结题,主持 
[10] 国家自然科学基金面上项目(青年基金项目),20604028,靶向性非病毒基因载 体改性聚乙烯亚胺的制备及研究,2007/01-2009/12,25万,已结题,主持
 

 


 
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