中文  English
人员介绍

汤朝晖

汤朝晖
姓 名:汤朝晖
邮 箱:ztang@ciac.ac.cn
职 称:研究员
研究方向:
 学习经历

1999 – 2005 中国科学院长春应用化学研究所,高分子化学与物理专业,理学博士,导师:陈学思 研究员;

1995 – 1999湘潭大学化学系,理学学士

工作经历

2015 –  研究员,中国科学院长春应用化学研究所

2009 – 2014 副研究员,中国科学院长春应用化学研究所

2007 – 2008 博士后,美国纽约州立大学石溪分校(State University of New York at Stony Brook

2005 – 2006 研究助理,英国帝国理工学院(Imperial College London

荣誉

2011年加入中国科学院青年创新促进会,2015年被评为青年创新促进会优秀会员。

研究兴趣

生物医用高分子在癌症治疗领域的应用,生物可降解高分子药物载体,纳米药物,肿瘤靶向药物传递,肿瘤免疫治疗

学术论文与专利情况

到目前为止,已在Chemical Science, Biomaterials, Small, Journal of controlled release, Biomacromolecules等上发表SCI研究论文74 篇,申请中国发明专利34项,其中23项已获授权,申请PCT专利1项。

1.      Yu, H.; Tang, Z.; Li, M.; Song, W.; Zhang, D.; Zhang, Y.; Yang, Y.; Sun, H.; Deng, M.; Chen, X., Cisplatin loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) complex nanoparticles for potential cancer therapy: preparation, in vitro and in vivo evaluation. J Biomed Nanotechnol. 2016, 12, 69-78.

2.      Song, W.; Tang, Z.; Zhang, D.; Li, M.; Gu, J.; Chen, X., A cooperative polymeric platform for tumor-targeted drug delivery. Chemical Science 2016.

3.      Yu, H.; Tang, Z.; Zhang, D.; Song, W.; Zhang, Y.; Yang, Y.; Ahmad, Z.; Chen, X., Pharmacokinetics, biodistribution and in vivo efficacy of cisplatin loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) complex nanoparticles for tumor therapy. J. Control. Release 2015, 205, 89-97.

4.      Yu, H.; Tang, Z.; Zhang, D.; Song, W.; Duan, T.; Gu, J.; Chen, X., Poly (ornithinecoargininecoglycinecoaspartic Acid): Preparation via NCA Polymerization and its Potential as a Polymeric TumorPenetrating Agent. Macromol. Biosci. 2015, 15, 829838.

5.      Yu, H.; Tang, Z.; Song, W.; Zhang, D.; Zhang, Y.; Chen, X., Co-administration of iRGD enhancing the anticancer efficacy of cisplatin-loaded polypeptide nanoparticles. J. Control. Release 2015, 213, e145-e146.

6.      Yifei Li, H. Y., Hai Sun, Jianguo Liu, Zhaohui Tang, Dan Wang, Lianyou Yu, Xuesi Chen, Cisplatin-loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) nanoparticlesas a potential chemotherapeutic agent against osteosarcoma. Chin. J. Polym. Sci. 2015, 33, 763-771.

7.      Song, W.; Tang, Z.; Zhang, D.; Yu, H.; Chen, X., Coadministration of Vascular Disrupting Agents and Nanomedicines to Eradicate Tumors from Peripheral and Central Regions. Small 2015, 11, 3755-3761.

8.      Song, W.; Tang, Z.; Zhang, D.; Burton, N.; Driessen, W.; Chen, X., Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography. RSC Adv. 2015, 5, 3807-3813.

9.      Shi, C.; Yu, H.; Sun, D.; Ma, L.; Tang, Z.; Xiao, Q.; Chen, X., Cisplatin-loaded polymeric nanoparticles: Characterization and potential exploitation for the treatment of non-small cell lung carcinoma. Acta Biomater. 2015, 18, 68–76.

10.   Li, M.; Tang, Z.; Zhang, D.; Sun, H.; Liu, H.; Zhang, Y.; Zhang, Y.; Chen, X., Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in rodent models. Biomaterials 2015, 51, 161-172.

11.   Feng, B.; Xu, Z.; Zhou, F.; Yu, H.; Sun, Q.; Wang, D.; Tang, Z.; Yu, H.; Yin, Q.; Zhang, Z.; Li, Y., Near infrared light-actuated gold nanorods with cisplatin-polypeptide wrapping for targeted therapy of triple negative breast cancer. Nanoscale 2015.

12.   Zhao, R.; Li, X.; Sun, B.; Zhang, Y.; Zhang, D.; Tang, Z.; Chen, X.; Wang, C., Electrospun chitosan/sericin composite nanofibers with antibacterial property as potential wound dressings. Int. J. Biol. Macromol. 2014, 68, 92-97.

13.   Yu, H.; Tang, Z.; Song, W.; Deng, M.; Chen, X., Current Status and Future Prospects of Polymeric Nanocarrier for Tumor Targeting. Chem. J. Chin. Univ.-Chin. 2014, 35, 903-916.

14.   Song, W.; Tang, Z.; Zhang, D.; Zhang, Y.; Yu, H.; Li, M.; Lv, S.; Sun, H.; Deng, M.; Chen, X., Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin. Biomaterials 2014, 35, 3005-3014.

15.   Song, W.; Tang, Z.; Li, M.; Lv, S.; Sun, H.; Deng, M.; Liu, H.; Chen, X., Polypeptide-based combination of paclitaxel and cisplatin for enhanced chemotherapy efficacy and reduced side-effects. Acta Biomater. 2014, 10, 1392-1402.

16.   Shao, J.; Tang, Z.; Sun, J.; Li, G.; Chen, X., Linear and Four-Armed Poly(L-lactide)-block-poly(D-lactide) Copolymers and Their Stereocomplexation with Poly(lactide)s. Journal of Polymer Science Part B-Polymer Physics 2014, 52, 1560-1567.

17.   Qu, Z.; Duan, R.; Pang, X.; Gao, B.; Li, X.; Tang, Z.; Wang, X.; Chen, X., Living and Stereoselective Polymerization of Rac-Lactide by Bimetallic Aluminum Schiff-Base Complexes. Journal of Polymer Science Part a-Polymer Chemistry 2014, 52, 1344-1352.

18.   Lv, S.; Tang, Z.; Zhang, D.; Song, W.; Li, M.; Lin, J.; Liu, H.; Chen, X., Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel. J. Control. Release 2014, 194, 220-227.

19.   Lv, S.; Tang, Z.; Li, M.; Lin, J.; Song, W.; Liu, H.; Huang, Y.; Zhang, Y.; Chen, X., Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer. Biomaterials 2014, 35, 6118-6129.

20.   Lv, S.; Song, W.; Tang, Z.; Li, M.; Yu, H.; Hong, H.; Chen, X., Charge-Conversional PEG-Polypeptide Polyionic Complex Nanoparticles from Simple Blending of a Pair of Oppositely Charged Block Copolymers as an Intelligent Vehicle for Efficient Antitumor Drug Delivery. Mol. Pharm. 2014, 11, 1562-1574.

21.   Li, Q.; Lv, S.; Tang, Z.; Liu, M.; Zhang, D.; Yang, Y.; Chen, X., A co-delivery system based on paclitaxel grafted mPEG-b-PLG loaded with doxorubicin: Preparation, in vitro and in vivo evaluation. Int. J. Pharm. 2014, 471, 412-420.

22.   Li, M.-q.; Tang, Z.-h.; Wang, C.; Zhang, Y.; Cui, H.-t.; Chen, X.-s., Efficient side-chain modification of dextran via base-catalyzed epoxide ring-opening and thiol-ene click chemistry in aqueous media. Chin. J. Polym. Sci. 2014, 32, 969-974.

23.   Li, M.; Tang, Z.; Zhang, Y.; Lv, S.; Yu, H.; Zhang, D.; Hong, H.; Chen, X., LHRH-peptide conjugated dextran nanoparticles for targeted delivery of cisplatin to breast cancer. J. Mat. Chem. B 2014, 2, 3490-3499.

24.   Li, M.; Tang, Z.; Lv, S.; Song, W.; Hong, H.; Jing, X.; Zhang, Y.; Chen, X., Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery. of doxorubicin. Biomaterials 2014, 35, 3851-3864.

25.   Li, M.; Tang, Z.; Lin, J.; Zhang, Y.; Lv, S.; Song, W.; Huang, Y.; Chen, X., Synergistic Antitumor Effects of Doxorubicin-Loaded Carboxymethyl Cellulose Nanoparticle in Combination with Endostar for Effective Treatment of Non-Small-Cell Lung Cancer. Adv. Healthc. Mater. 2014, 3, 1877-1888.

26.   Guo, Z.; Tian, H.; Lin, L.; Chen, J.; He, C.; Tang, Z.; Chen, X., Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier. Macromol. Biosci. 2014, 14, 1406-1414.

27.   Chen, J.; Xia, J.; Tian, H.; Tang, Z.; He, C.; Chen, X., Thermo-/pH-dual responsive properties of hyperbranched polyethylenimine grafted by phenylalanine. Arch. Pharm. Res. 2014, 37, 142-148.

28.   Ahmad, Z.; Tang, Z.; Shah, A.; Lv, S.; Zhang, D.; Zhang, Y.; Chen, X., Cisplatin Loaded Methoxy Poly (ethylene glycol)-block-Poly (L-glutamic acid-co-L-Phenylalanine) Nanoparticles against Human Breast Cancer Cell. Macromol. Biosci. 2014, 14, 1337-1345.

29.   Zhao, L.; Xiao, C.; Ding, J.; He, P.; Tang, Z.; Pang, X.; Zhuang, X.; Chen, X., Facile one-pot synthesis of glucose-sensitive nanogel via thiol-ene click chemistry for self-regulated drug delivery. Acta Biomater. 2013, 9, 6535-6543.

30.   Zhao, L.; Ding, J.; Xiao, C.; He, P.; Tang, Z.; Chen, X., Phenylboronic acid functionalized polypeptide micelles for glucose-responsive insulin release at physiological pH. J. Control. Release 2013, 172, E110-E110.

31.   Lv, S.; Li, M.; Tang, Z.; Song, W.; Sun, H.; Liu, H.; Chen, X., Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efficient drug delivery system for cancer therapy. Acta Biomater. 2013, 9, 9330-9342.

32.   Li, M.; Tang, Z.; Sun, H.; Ding, J.; Song, W.; Chen, X., pH and reduction dual-responsive nanogel cross-linked by quaternization reaction for enhanced cellular internalization and intracellular drug delivery. Polym. Chem. 2013, 4, 1199-1207.

33.   Li, M.; Song, W.; Tang, Z.; Lv, S.; Lin, L.; Sun, H.; Li, Q.; Yang, Y.; Hong, H.; Chen, X., Nanoscaled Poly(L-glutamic acid)/Doxorubicin-Amphiphile Complex as pH-responsive Drug Delivery System for Effective Treatment of Nonsmall Cell Lung Cancer. Acs Applied Materials & Interfaces 2013, 5, 1781-1792.

34.   Li, M.; Lv, S.; Tang, Z.; Song, W.; Yu, H.; Sun, H.; Liu, H.; Chen, X., Polypeptide/Doxorubicin Hydrochloride Polymersomes Prepared Through Organic Solvent-free Technique as a Smart Drug Delivery Platform. Macromol. Biosci. 2013, 13, 1150-1162.

35.   Li, D.; Sun, H.; Ding, J.; Tang, Z.; Zhang, Y.; Xu, W.; Zhuang, X.; Chen, X., Polymeric topology and composition constrained polyether-polyester micelles for directional antitumor drug delivery. Acta Biomater. 2013, 9, 8875-8884.

36.   Huang, Y.; Tang, Z.; Zhang, X.; Yu, H.; Sun, H.; Pang, X.; Chen, X., pH-Triggered Charge-Reversal Polypeptide Nanoparticles for Cisplatin Delivery: Preparation and In Vitro Evaluation. Biomacromolecules 2013, 14, 2023-2032.

37.   He, P.; Zhao, C.-w.; Xiao, C.-s.; Tang, Z.-h.; Chen, X.-s., Thermosensitive polyion complex micelles prepared by self-assembly of two oppositely charged diblock copolymers. Chin. J. Polym. Sci. 2013, 31, 318-324.

38.   He, P.; Liu, H.; Tang, Z.; Deng, M.; Yang, Y.; Pang, X.; Chen, X., Poly(ester amide) blend microspheres for oral insulin delivery. Int. J. Pharm. 2013, 455, 259-266.

39.   He, C.; Tang, Z.; Tian, H.; Chen, X., Progress in the Development of Biomedical Polymer Materials Fabricated by 3-Dimensional Printing Technology. Acta Polymerica Sinica 2013, 722-732.

40.   Guo, J.; Li, X.; Yu, H.; Tang, Z.; Tang, X.; Cai, C.; Xu, J.; Xu, H., The anti-melanoma efficiency of the intratumoral injection of cucurbitacin-loaded sustained-release carriers: A PLGA particle system. J. Pharm. Sci. 2013, 102, 2550-2563.

41.   Gao, B.; Duan, R.; Pang, X.; Li, X.; Qu, Z.; Tang, Z.; Zhuang, X.; Chen, X., Stereoselective Ring-Opening Polymerization of rac-Lactides Catalyzed by Aluminum Hemi-Salen Complexes. Organometallics 2013, 32, 5435-5444.

42.   Zhao, L.; Ding, J.; Xiao, C.; He, P.; Tang, Z.; Pang, X.; Zhuang, X.; Chen, X., Glucose-sensitive polypeptide micelles for self-regulated insulin release at physiological pH. J. Mater. Chem. 2012, 22, 12319-12328.

43.   Tian, H.; Tang, Z.; Zhuang, X.; Chen, X.; Jing, X., Biodegradable synthetic polymers: Preparation, functionalization and biomedical application. Prog. Polym. Sci. 2012, 37, 237-280.

44.   Song, W.; Xiao, C.; Cui, L.; Tang, Z.; Zhuang, X.; Chen, X., Facile construction of functional biosurface via SI-ATRP and "click glycosylation". Colloid Surf. B-Biointerfaces 2012, 93, 188-194.

45.   Song, W.; Tang, Z.; Li, M.; Lv, S.; Yu, H.; Ma, L.; Zhuang, X.; Huang, Y.; Chen, X., Tunable pH-Sensitive Poly(beta-amino ester)s Synthesized from Primary Amines and Diacrylates for Intracellular Drug Delivery. Macromol. Biosci. 2012, 12, 1375-1383.

46.   Song, W.; Li, M.; Tang, Z.; Li, Q.; Yang, Y.; Liu, H.; Duan, T.; Hong, H.; Chen, X., Methoxypoly(ethylene glycol)-block-Poly(L-glutamic acid)-Loaded Cisplatin and a Combination With iRGD for the Treatment of Non-Small-Cell Lung Cancers. Macromol. Biosci. 2012, 12, 1514-1523.

47.   Li, D.; Ding, J. X.; Tang, Z. H.; Sun, H.; Zhuang, X. L.; Xu, J. Z.; Chen, X. S., In vitro evaluation of anticancer nanomedicines based on doxorubicin and amphiphilic Y-shaped copolymers. Int. J. Nanomedicine 2012, 7, 2687-2697.

48.   He, P.; Tang, Z.; Lin, L.; Deng, M.; Pang, X.; Zhuang, X.; Chen, X., Novel Biodegradable and pH-Sensitive Poly(ester amide) Microspheres for Oral Insulin Delivery. Macromol. Biosci. 2012, 12, 547-556.

49.   He, C.; Zhuang, X.; Tang, Z.; Tian, H.; Chen, X., Stimuli-Sensitive Synthetic Polypeptide-Based Materials for Drug and Gene Delivery. Adv. Healthc. Mater. 2012, 1, 48-78.

50.   Zhuang, X.-l.; Yu, H.-y.; Tang, Z.-h.; Oyaizu, K.; Nishide, H.; Chen, X.-s., POLYMERIZATION OF LACTIC O-CARBOXYLIC ANHYDRIDE USING ORGANOMETALLIC CATALYSTS. Chin. J. Polym. Sci. 2011, 29, 197-202.

51.   Zhao, L.; Ding, J.; He, P.; Xiao, C.; Tang, Z.; Zhuang, X.; Chen, X., An efficient pH sensitive oral insulin delivery system enhanced by deoxycholic acid. J. Control. Release 2011, 152, E184-E186.

52.   Wang, W.; Ding, J.; Xiao, C.; Tang, Z.; Li, D.; Chen, J.; Zhuang, X.; Chen, X., Synthesis of Amphiphilic Alternating Polyesters with Oligo(ethylene glycol) Side Chains and Potential Use for Sustained Release Drug Delivery. Biomacromolecules 2011, 12, 2466-2474.

53.   Ding, J.; Zhuang, X.; Xiao, C.; Cheng, Y.; Zhao, L.; He, C.; Tang, Z.; Chen, X., Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery. J. Mater. Chem. 2011, 21, 11383-11391.

54.   Ding, J.; Xiao, C.; Zhao, L.; Cheng, Y.; Ma, L.; Tang, Z.; Zhuang, X.; Chen, X., Poly(L-glutamic acid) Grafted with Oligo(2-(2-(2-methoxyethoxy)ethoxy) ethyl methacrylate): Thermal Phase Transition, Secondary Structure, and Self-Assembly. Journal of Polymer Science Part a-Polymer Chemistry 2011, 49, 2665-2676.

55.   Ding, J.; Xiao, C.; Yan, L.; Tang, Z.; Zhuang, X.; Chen, X.; Jing, X., pH and dual redox responsive nanogel based on poly(l-glutamic acid) as potential intracellular drug carrier. J. Control. Release 2011, 152, E11-E13.

56.   Ding, J.; Xiao, C.; Tang, Z.; Zhuang, X.; Chen, X., Highly Efficient "Grafting From" an alpha-Helical Polypeptide Backbone by Atom Transfer Radical Polymerization. Macromol. Biosci. 2011, 11, 192-198.

57.   Xiao, C.; Zhao, C.; He, P.; Tang, Z.; Chen, X.; Jing, X., Facile Synthesis of Glycopolypeptides by Combination of Ring-Opening Polymerization of an Alkyne-Substituted N-carboxyanhydride and Click "Glycosylation". Macromol. Rapid Commun. 2010, 31, 991-997.

58.   Wan, F.; Tang, Z.; He, W.; Chu, B., A chemistry/physics pathway with nanofibrous scaffolds for gene delivery. PCCP 2010, 12, 12379-12389.

59.   Pang, X.; Zhuang, X.; Tang, Z.; Chen, X., Polylactic acid (PLA): Research, development and industrialization. Biotechnology Journal 2010, 5, 1125-1136.

60.   Tang, Z. H.; Qiu, C. Q.; McCutcheon, J. R.; Yoon, K.; Ma, H. Y.; Fang, D. F.; Lee, E.; Kopp, C.; Hsiao, B. S.; Chu, B., Design and Fabrication of Electrospun Polyethersulfone Nanofibrous Scaffold for High-Flux Nanofiltration Membranes. Journal of Polymer Science Part B-Polymer Physics 2009, 47, 2288-2300.

61.   Tang, Z.; Wei, J.; Yung, L.; Ji, B.; Ma, H.; Qiu, C.; Yoon, K.; Wan, F.; Fang, D.; Hsiao, B. S.; Chu, B., UV-cured poly(vinyl alcohol) ultrafiltration nanofibrous membrane based on electrospun nanofiber scaffolds. J. Membr. Sci. 2009, 328, 1-5.

62.   Tang, Z.; Gibson, V. C., rac-Lactide polymerization using aluminum complexes bearing tetradentate phenoxy-amine ligands. Eur. Polym. J. 2007, 43, 150-155.

63.   Yang, Y. K.; Tang, Z. H.; Pang, X.; Du, H. Z.; Chen, X. S.; Jing, X. B., Stereoselective polymerization of rac-lactide initiated by achiral Schiff-base isopropoxide aluminum complex. Chem. J. Chin. Univ.-Chin. 2006, 27, 352-355.

64.   Tang, Z.; Pang, X.; Sun, J.; Du, H.; Chen, X., Five-coordinated active species in the stereoselective polymerization of rac-lactide using N,N '-(2,2-dimethyl-1,3-propylene)bis(3,5-di-tert-butyl-salicylideneimine) aluminum complexes. Journal of Polymer Science Part a-Polymer Chemistry 2006, 44, 4932-4938.

65.   Tang, Z. H.; Yang, Y. K.; Pang, X.; Hu, J. L.; Chen, X. S.; Hu, N. H.; Jing, X. B., Controlled and stereospecific polymerization of rac-lactide with a single-site ethyl aluminum and alcohol initiating system. J. Appl. Polym. Sci. 2005, 98, 102-108.

66.   Hu, J. L.; Tang, Z. H.; Qiu, X. Y.; Pang, X.; Yang, Y. K.; Chen, X. S.; Jing, X. B., Formation of flower-or cake-shaped stereocomplex particles from the stereo multiblock copoly(rac-lactide)s. Biomacromolecules 2005, 6, 2843-2850.

67.   Hu, J.; Tang, Z.; Qiu, X.; Han, Y.; Du, Q.; Chen, X.; Jing, X., Effects of Stereoregularity of Multiblock Copoly(rac-lactide)s on Stereocomplex Microparticles and Their Insulin Delivery. Macromol. Biosci. 2005, 5, 1193-1199.

68.   Guan, H. L.; Xie, Z. G.; Tang, Z. H.; Xu, X. Y.; Chen, X. S.; Jing, X. B., Preparation of block copolymer of epsilon-caprolactone and 2-methyl-2-carboxyl-propylene carbonate. Polymer 2005, 46, 2817-2824.

69.   Deng, C.; Rong, G. Z.; Tian, H. Y.; Tang, Z. H.; Chen, X. S.; Jing, X. B., Synthesis and characterization of poly(ethylene glycol)-b-poly (L-lactide)-b-poly(L-glutamic acid) triblock copolymer. Polymer 2005, 46, 653-659.

70.   Tang, Z. H.; Chen, X. S.; Yang, Y. K.; Pang, X.; Sun, J. R.; Zhang, X. F.; Jing, X. B., Stereoselective polymerization of rac-lactide with a bulky aluminum/Schiff base complex. Journal of Polymer Science Part a-Polymer Chemistry 2004, 42, 5974-5982.

71.   Tang, Z. H.; Chen, X. S.; Pang, X.; Yang, Y. K.; Zhang, X. F.; Jing, X. B., Stereoselective polymerization of rac-lactide using a monoethylaluminum Schiff base complex. Biomacromolecules 2004, 5, 965-970.

72.   Sun, J. R.; Hong, Z. K.; Yang, L. X.; Tang, Z. H.; Chen, X. S.; Jing, X. B., Study on crystalline morphology of poly(L-lactide)-poly(ethylene glycol) diblock copolymer. Polymer 2004, 45, 5969-5977.

73.   Tang, Z. H.; Chen, X. S.; Hang, Q. Z.; Bian, X. C.; Yang, L. X.; Piao, L. H.; Jing, X. B., Strontium-based initiator system for ring-opening polymerization of cyclic esters. Journal of Polymer Science Part a-Polymer Chemistry 2003, 41, 1934-1941.

74.   Rong, G. Z.; Deng, M. X.; Deng, C.; Tang, Z. H.; Piao, L. H.; Chen, X. S.; Jing, X. B., Synthesis of poly(epsilon-caprolactone)-b-poly(gamma-benzyl-L-glutamic acid) block copolymer using amino organic calcium catalyst. Biomacromolecules 2003, 4, 1800-1804.

 

 

[下一个人员:田华雨]→

电话: +86-431-85262367
传真: +86-431-85262933
E-mail: xiaocs@ciac.ac.cn
地址: 中国·吉林省长春市人民大街5625号 吉ICP备10201110号-2