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Employees are introduced

Chaoliang He

Chaoliang He
Name:Chaoliang He
E-mail:clhe@ciac.ac.cn
Lab Status:Professor
Research direction:
 I. PERSONAL INFORMATION:

Name:             He, Chaoliang

Current Position:   Professor

Affiliation:         Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

Present Address:    5625 Renmin Street, Changchun 130022, Jilin, China

Tel:               0431-85262116

E-mail Address:    clhe@ciac.ac.cn

 

II. Research Fields:

(1)  Injectable polypeptide hydrogels for biomedical applications

(2)  Injectable hydrogels for localized anti-cancer drug delivery, hydrogel-based scaffolds for tissue regeneration

(3)  Stimuli-responsive and bioactive polymers

 

III. EDUCATION:

2001.9 – 2007.1, Ph.D., Polymer Chemistry and physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.

1997.9 – 2001.7, Bachelor of Engineering, Applied Chemistry, East China University of Science and Technology; Shanghai, China.

 

IV. WORK EXPERIENCE

2016.1 –, Professor, Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

2010.9 – 2015.12, Associate Professor, Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

2008.11 – 2010.8, Postdoctoral Fellow, Ottawa Health Research Institute, University of Ottawa, Ottawa, ON K1H 8L6, Canada.

2007.3 – 2008.8, Postdoctoral Fellow, Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, South Korea.

 

V. SELECTED RECENT PUBLICATIONS:

1.       Chaoliang He, Zhaohui Tang, Huayu Tian, Xuesi Chen*. Co-delivery of chemotherapeutics and proteins for synergistic therapy. Advanced Drug Delivery Reviews 2016, 98, 64-76.

2.       Qinghua Xu, Chaoliang He*, Kaixuan Ren, Chunsheng Xiao, Xuesi Chen*. Thermosensitive polypeptide hydrogels as a platform for ROS-triggered cargo release with innate cytoprotective ability under oxidative stress. Advanced Healthcare Materials 2016, 5(15), 1979-1990.

3.       Qinghua Xu, Chaoliang He*, Chunsheng Xiao, Xuesi Chen*. Reactive oxygen species (ROS) responsive polymers for biomedical applications. Macromolecular Bioscience 2016, 16(5), 635-646.

4.       Xilong Wu, Chaoliang He*, Yundi Wu, Xuesi Chen*. Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model. Biomaterials 2016, 75, 148-162.

5.       Zhaohui Tang, Chaoliang He, Huayu Tian, Jianxun Ding, Benjamin S Hsiao*, Benjamin Chu, Xuesi Chen*. Polymeric nanostructured materials for biomedical applications. Progress in Polymer Science 2016, DOI: 10.1016/j.progpolymsci.2016.05.005.

6.       Kaixuan Ren, Chaoliang He*, Chunsheng Xiao, Gao Li*, Xuesi Chen. Injectable glycopolypeptide hydrogels as biomimetic scaffolds for cartilage tissue engineering. Biomaterials 2015, 51, 238-249.

7.       Qinghua Xu, Chaoliang He*, Chunsheng Xiao, Shuangjiang Yu, Xuesi Chen*. ε-methacryloyl-L-Lysine based polypeptides and their thiol-ene click functionalization. Polymer Chemistry 2015, 6(10), 1758-1767.

8.       Xilong Wu, Chaoliang He, Yundi Wu, Xuesi Chen*, Jianjun Cheng*. Nanogel-incorporated physical and chemical hybrid gels for highly effective chemo-protein combination therapy. Advanced Functional Materials 2015, 25 (43), 6744-6755.

9.       Kaixuan Ren, Chaoliang He*, Yilong Cheng, Gao Li*, Xuesi Chen. Injectable enzymatically crosslinked hydrogels based on a poly(L-glutamic acid) graft copolymer. Polymer Chemistry 2014, 5(17), 5069-5076.

10.    Shuangjiang Yu, Jianxun Ding, Chaoliang He*, Yue Cao, Weiguo Xu, Xuesi Chen. Disulfide cross-linked polyurethane micelles as a reduction-triggered drug delivery system for cancer therapy. Advanced Healthcare Materials 2014, 3(5), 752-760.

11.    Xiaoye Gao, Yue Cao, Xiangfu Song, Zhe Zhang, Chunsheng Xiao, Chaoliang He*, Xuesi Chen. pH- and thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid derivative) copolymers and hydrogels with LCST dependent on pH and alkyl side groups. Journal of Materials Chemistry B 2013, 1(41), 5578-5587.

12.    Shuangjiang Yu, Chaoliang He*, Jianxun Ding, Yilong Cheng, Wantong Song, Xiuli Zhuang, Xuesi Chen. pH and reduction dual responsive polyurethane triblock copolymers for efficient intracellular drug delivery. Soft Matter 2013, 9(9), 2637-2645.

13.    Kaixuan Ren, Yilong Cheng, Chaoliang He*, Chunsheng Xiao, Gao Li*, Xuesi Chen. The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers. Polymer 2013, 54(9), 2466-2472.

14.    Yilong Cheng, Chaoliang He, Jianxun Ding, Chunsheng Xiao, Xiuli Zhuang, Xuesi Chen*. Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs. Biomaterials 2013, 34(38), 10338-10347.

15.    Yilong Cheng, Chaoliang He, Chunsheng Xiao, Jianxun Ding, Haitao Cui, Xiuli Zhuang, Xuesi Chen*. Versatile biofunctionalization of polypeptide-based thermosensitive hydrogels via click chemistry. Biomacromolecules 2013, 14(2), 468-475.

16.    Chaoliang He, Xiuli Zhuang, Zhaohui Tang, Huayu Tian, Xuesi Chen*. Stimuli-sensitive synthetic polypeptide-based materials for drug and gene delivery. Advanced Healthcare Materials 2012, 1 (1), 48-78.

17.    Yilong Cheng, Chaoliang He, Chunsheng Xiao, Jianxun Ding, Xiuli Zhuang, Yubin Huang, Xuesi Chen*. Decisive role of hydrophobic side groups of polypeptides in thermosensitive gelation. Biomacromolecules 2012, 13 (7), 2053-2059.

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