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General Station
         Since its founding in 1999, Biomedical Polymer Group have made great achievements in scientific research, personnel training, acdemic exchanges, transformation of scientific findings and so on. As of 2008, the group has published more than 150 academic articles, including 22 national publications and 130 publications abroad, a works (Translation), and applicated 55 invention patents (except the authorized ones) totally. The group has abundant research power, has been undertaking over 70 projects including state-level and province-level items, and has gained technology awards all levels many times. There are 32 staff, and more then 80 mobile staff (including senior visiting scholars, post-doctoral, doctor, masters, etc.) in the group, and more than 1160 square meters of office space, the experimental environment has been the first-class.
Main Research Interests
         Our research interests mainly focus on the functionalization and intelligentization of polyester and poly(amino acid)-based polymers, synthesis of biodegradable stimuli-responsive hydrogels, preparation of amphiphilic hyperbranched copolymers and their application as noviral gene carriers, synthesis of stereoselective catalyst for ring-opening polymerization of cyclic ester, preparation of ultrafine fibers by electrospinning, synthesis of electroactive biodegradable polymers for tissue engineering applications, studies of the crystallization behavior and morphology development of aliphatic polyester and their copolymers.
Representative scientific research
         Because of the biocompatible and biodegradable, aliphatic polyesters have been widely applied in biomedical materials field, such as drug delivery vehicles and tissue engineering. However, the hydrophobic nature and lack of functional groups of the polyesters have hindrances to their applications. Accordingly, we have synthesized a variety of functional α-amino acid derivatives and carbonate monomers with reactive side groups such as carboxyl, hydroxyl and amino groups. Copolymerizations of the functional monomers with cyclic esters monomers have afford polyesters with side chains functionalities. After deprotection, the reactive side groups were used to conjugate anti-cancer drug paclitaxel, RGD peptides or sugars, leading to materials with functional, targeting and intelligent features, which may have new potential applications in biomedical materials. Coupling reaction between branched polyethylenimine (PEI) and Polyethylene glycol was conducted to get copolymer PEG-PEI. Then, poly(ethyleneglycol)-polyethylenimine-poly(-benzyl-glutamate)(PEG-PEI-PBLG)orpolyethylenimine-poly(-benzylL-glutamate)(PEI-PBLG) block copolymer was successfully synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of -benzyl-L-glutamate (BLG-NCA) with PEG-PEI or PEI as a macroinitiator. Comparing with commercial PEI, PEI-PBLG has one times higher transfection efficiency, and it has the most excellent general performance in the reported non-viral vector about PEI. Synthesized various types of biodegradable polymer materials were used as basic research for tissue engineering of bone, internal and external fracture fixation, in vivo tubular organization repairing scaffold, adriamycin, taxol, rifampicin and microfiber drug release. Also, biological properties, mechanical properties, degradation were evaluated, and animal experiments, clinical trials exploration were carried through. In 2006, the industrialization project of PLLA send about 1.5 million RMB to our group for the research. Two kinds of catalyst used in the oligo-polymerization of lactic acid and the subsequent decomposition, polymerization. The desi
gn, installation and testing of equipment for 5000 t/year demonstration process line were finished. The test run began from Oct 8, 2006, now, the whole producing technology has been achieved, and further optimization of the processing technology will run formally. Make a thorough investigation about each procedure of the processing technology and obtain feasible PLLA production technology with independent intellectual property. As for the PLLA manufacture, technologies of injection, extrusion and biaxial stretching were achieved; cups, barrals, disks, tableware, board, pipes and packaging films were produced.

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E-mail: xiaocs@ciac.ac.cn
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